Journal article
Quantitatively Tracking Bio-Nano Interactions of Metal-Phenolic Nanocapsules by Mass Cytometry
S Li, Y Ju, J Zhou, KF Noi, AJ Mitchell, T Zheng, SJ Kent, CJH Porter, F Caruso
ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2021
Abstract
Polymer nanocapsules, with a hollow structure, are increasingly finding widespread use as drug delivery carriers; however, quantitatively evaluating the bio-nano interactions of nanocapsules remains challenging. Herein, poly(ethylene glycol) (PEG)-based metal-phenolic network (MPN) nanocapsules of three sizes (50, 100, and 150 nm) are engineered via supramolecular template-assisted assembly and the effect of the nanocapsule size on bio-nano interactions is investigated using in vitro cell experiments, ex vivo whole blood assays, and in vivo rat models. To track the nanocapsules by mass cytometry, a preformed gold nanoparticle (14 nm) is encapsulated into each PEG-MPN nanocapsule. The results..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
This research was supported by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project no. CE140100036). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (no. GNT1135806). Y.J. acknowledges the award of an Early Career Researcher Grant from The University of Melbourne (no. ECR1032020). This work was performed in part at the Materials Characterisation and Fabrication Platform at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility. The authors acknowledge Dr Hannah Gabrielle Kelly for helpful discussions and assistance with the whole blood assays.